Poloxamer basf pdf files

Thermosensitive micelleshydrogel hybrid system based on. Pdf synthesis and characterization of poloxamer 188. Use this chart to help guide your component selection. Comparative study of poloxamer insertion into lipid monolayers. Apr 11, 2014 poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. Multiblock poloxamer surfactants suppress aggregation of denatured proteins article pdf available in biochimica et biophysica acta 17801. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Serasense sf 2 dimethicone cleanses oils away, whilst serasense cf cpm caprylyl methicone smoothes the eye area without tackiness. Solid dispersions of pioglitazone hcl with pvp k30, hpmc, peg 6000, eudragit epo and poloxamer 407 shows 75%, 74%, 100%, 50% and 62% release respectively after 30 minutes where as pioglitazone hcl shows only 12.

Based on its pkpd ratios, doxycycline hyclate doxh, a timedependant antibacterial, is ideally expected to achieve both sustained plasma drug concentrations at or slightly above the mic level for as long as possible between dosing intervals. Pharmacokinetics of an injectable longacting formulation. Ahmed department pharmaceutics and industrial pharmacy, faculty. The triblock copolymer surfactant poloxamer 188 p188 is known to increase the cell survival after membrane electroporation 8,22. Pxm188 is an aba block type copolymer which contains around 80% poe units and 20% ppo units. Basf is the first company in the world to offer triphenylphosphine tpp in the form of pellets. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Solid dispersions of pioglitazone hcl with pvp k30, hpmc, peg 6000, eudragit epo and poloxamer 407 shows 75%, 74%, 100%, 50% and 62% release respectively after 30 minutes where. Introduction enterococcus faecalis is a key pathogen recovered from root canals when conventional treatment fails. Table1 shows examples of commercially available pluronics. A sustainedrelease formulation using specific phages against e.

The adverse effects of these techniques are wellknown, and researches have been trying to find out new materials to occlude the coronary artery without an endothelial damage. Please cite this article in press as ramkumar ponnuraj et al. Basf corporation evaluation of lutrol f grades prill vs. Poloxamer 188 facilitates the repair of alveolus resident. The process involves premelting the poloxamer prior to mixing with cold water. Poloxamer macromers synthesis and characterization poloxamer 407 was rst dried by azeotropic distillation with toluene using a dean stark apparatus and then chainextended by ring opening polymerization of either. Poloxamer was gift sample from basf mumbai, chitosan, sodium chloride, sodium hydrogen carbonate, calcium chloride and sodium hydroxide pellets were purchased from puna chemicals, pune. Then, the impact of poloxamer 407 concentration on gel formation was evaluated. Pdf poloxamers, poloxamines and polymeric micelles. Manager, regulatory affairs, north america basf corporation excipientfest meeting, pr, may 5, 2010 12. Effects of temporary vascular occluder poloxamer 407 gel. An appropriate amount of all poloxamers poloxamer 407, 237, and 108 with different concentra.

Method preformulation studies ftir studies the possibility of drugexcipient interactions can be investigated by ftir. Used as an emulsifying agent in intravenous fat emulsions, and as solubilizing agent to maintain the clarity of elixirs and syrups. Basf offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. White to slightly yellowish waxy substance in the form of micropearls. Hydrogelbased reinforcement of 3d bioprinted constructs 4 2. Evaluation of microneedlesassisted in situ depot forming. By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. May also be used as a wetting agent in eye drops, ointments, suppository bases, gels, and. Here, we use a rat hindlimb model of electroporation injury to determine if the intravenous administration of p188 improves the recovery of the muscle function. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. Effects of poloxamer and hpmc on the dissolution of.

Determination of poloxamer 188 and poloxamer 407 using high. Technical information basf auxiliaries for textile printing. Basf is the worlds leading chemical company, and has a portfolio ranging from chemicals, plastics and performance products to. Wo2009055312a1 process for producing a poloxamer gel. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. Us drug master file basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorizations. Basf, ludwigshafen, germany was prepared in a stock solution of 100 mgml by dissolving it in sterile water overnight and filtering it through a 0. Formulation and characterization of rosuvastatin calcium. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of. Used in toothpaste, whitening gels, mouthwash, sun and skin care applications. These surfactants were introduced in the 1950s basf, mount olive, nj and p188 was one of the first to. Weitz, school of engineering and applied sciences and department of physics, harvard university, cambridge, massachusetts 028. Thermogelling properties of purified poloxamer 407. Through science and innovation we provide our customers with products to meet the current and future needs of business and society.

Structural and functional recovery of electropermeabilized skeletal muscle invivo after treatment with surfactant poloxamer 188 john m. The poloxamer synperonic f108 stock solution was stored at 4c. Chemical nature poloxamer block copolymers are non ionic surfactants available under the pluracare registered trade name. Excipients for future discovery, and regulatory journey. Preparation of poloxamer solutions poloxamer solutions were prepared using the cold method. Clonazepam is an anticonvulsant and anxiolytic drug characterized by poor solubility and rapid absorption. Formulation and evaluation of thermosensitive in situ gel. The impurities of commercial grade poloxamer 188, as an example. Thermogelling properties of purified poloxamer 407 ncbi. Effect of poloxamer 407 as a carrier vehicle on rotator. Formulation and characterization of rosuvastatin calcium nanoparticles ramkumar ponnuraj1. Lutrol f 127 it is recommended to use a preparation of the poloxamer with. Moreover, kolliphor p 407 is suitable for the formulation of active substances that show reduced solubility as well as chemical stability as a result of neutralization of gel formulations.

Structural and functional recovery of electropermeabilized. Accurately weighed quantities of hpmc e5, poloxamer 188, and sacrificial excipients spraydried lactose or pregelatinized starch were. Active substances that are insoluble in water are dissolved in ethanol, isopropanol or propylene glycol at 70 c and mixed with the warm aqueous phase to form a homogeneous mass. Evaluation of hydroperoxides in common pharmaceutical. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Swelling behavior the swelling ratio sr of hydrogels was measured in. International journal of advances in pharmacy, biology and chemistry research article containing solubilised tea tree oil for vaginal infections abstract vagina shows dynamic changes in its microbial population due to menstruation, douching, coitus, contraception and menopause. View all us drug master files dmf, dmfs filed by basf with the fda on list of drug master files dmf of active pharmaceutical ingredients apis submissions by basf to the u. Basf to develop a high purity poloxamer for mast therapeutics.

Hot process lutrol f 127 is dissolved in water at approx. The formation of micelles and, consequently, their size. They make this highlyefficient intermediate, used in many types of applications, significantly easier and safer to handle. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers.

Poloxamer selfassembly in aqueous solutions poloxamers are available in a broad range of molecular weights and ppopeo ratios. Poloxamer 188 pxm188 and poloxamer 407 pxm407 are among the most commonly used pxms. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties.

We combine economic success with environmental protection and social responsibility. Polypropylene chemical compatibility chart this polypropylene chemical compatibility chart is a shorthand tool for describing the suitability of miniature fluidic and pneumatic polypropylene components for use in contact with various chemicals. Pdf multiblock poloxamer surfactants suppress aggregation. Dual phase eye make up remover ec1 this dual phase formulation blends together to remove all eye make up, including waterproof. Technical information pluracare lf grades poloxamer. Nov 17, 2014 commercial grades nonproprietry name commercial grades poloxamer 124 l44 poloxamer 184 l64 poloxamer 185 p65 poloxamer 188 f68 poloxamer 237 f87 poloxamer 338 f108 poloxamer 407 f127 24. Moreover, most studies have evaluated the healing process using different carrier vehicles, each of which may have specific effects on tendon. Rearrange individual pages or entire files in the desired order. Solid dispersion formulations of pioglitazone hcl using five.

Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj. Basf to develop a high purity poloxamer for mast therapeutics news provided by. Information material on polyurethane products and systems. All excipients are compendial grade unless otherwise noted. The possible nanoemulsion region of combinations of these excipients was described in ternary phase diagrams. Micronized poloxamer 407, hpmc 6 cps and hpc were utilized for this purpose. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Solid dispersion formulations of pioglitazone hcl using. Assessment of transdermal penetration enhancement by topical. List of drug master files dmf of poloxamer 182lf active pharmaceutical ingredient api submitted to the u.

Research paper silver sulfadiazine based cubosome hydrogels for topical treatment of burns. Numerous studies have provided various alternative modi. Ris procite, reference manager, endnote, bibtex, medlars, refworks. P108, p188, p238, p338 basf, parsippany, nj per milliliter of ultrapure water were prepared by adding the poloxamer and water to a vial containing a magnetic stir bar and then left to mix on a stirplate for up to2htoensure complete dissolution of the poloxamer. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers. Deionized water was obtained from millipore filtration system, usa. Thermosensitive micelleshydrogel hybrid system based on poloxamer 407 2709 and g were equivalent in value. The present investigation was undertaken with the objective of formulating tc containing fast dissolving films for local delivery to oral cavity. Information material on polyurethane systems and products basf. January 26, 2016 dear prof sun, heriotwatt university. Sep 18, 2014 register now and get a free online msds binder. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg.

Nanoparticles of egcg is prepared using cs as a coating material by ionic gelation method, where the positively charged. Various film forming agents, film modifiers and polyhydric alcohols were evaluated for optimizing the composition of fast dissolving films. Is determined by the chain length of the polyethylene eo units and polyoxypropylene po. Pdf poloxamer 188 is a safe biocompatible polymer that can be used in protein drug delivery system. Basf poloxamers offer better solubilizing properties compared to hpmc, pvp. Poloxamers are nonionic polyoxyethylenepolyoxypropylene copolymers used primarily as emulsifiers, solubilizing agents, wetting agents and have been reported for enhancing the solubility and bioavailability of. Differential effects of commercialgrade and purified. Relevant identified uses of the substance or mixture and uses advised against use of the substancemixture. The methods of determination are described in this monograph or in the general methods to be found in the european pharmacopoeia. The disintegration time of all the formulations were found to be less than 42 sec. Synthesis of mono and dimethacrylated poloxamer 188 mmp and dmp components were added to a glass roundbottomed flask in the amounts stated in table 1 according to the following procedure. They are also used in topical dosage forms and rectal suppositories. Basf offers a wide selection of solubilizers, solvents and matrices for solid solutions and dispersions, and liquid.

Enhancement of solubility and dissolution properties of. Lutrol f 68 meets the requirements of the current uspnf family monograph, poloxamer. Publications performance and formulation additives basf. In vivo studies showing the effects of biologic healingpromoting factors on tendontobone healing after rotator cuff repair have focused only on biologic healingpromoting factors and have not taken into consideration the effect of the carrier vehicle. Differently, viscosities of p407cmcsga solutions were continuously measured at 20 c, and data were recorded automatically for 2 min. Poloxamer 188 was dissolved in dcm 275 ml for monomethacrylation. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. We continually provide comprehensive safety and regulatory data on our safety data sheets promoting safe usage and handling of our products.

Poloxamer 188 was obtained as gift sample from basf corporation north america. Details of the supplier of the safety data sheet monument chemical 2450 olin road. What links here related changes upload file special pages permanent link. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb. Pursuing this end, a poloxamerbased matrix was used to produce a longacting injectable preparation doxhla and its serum concentrations vs. Basf maintains a drug master file for poloxamers at the fda and. Acetonitrile and methanol hplc grade were purchased from sd fine chemicals mumbai.

A supercritical fluid extraction process was used to prepare p188p. Excipients for future discovery, and regulatory journey to market ranga velagaleti, ph. Poloxamers, available also under the trademark pluronics basf, are a. Download all tables of the basf report 2014 as excel files.

Phage therapy has generated new interest in combating pathogens. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Poloxamer 188 was purchased from basf mumbai, india and. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. Design and evaluation of rapidly disintegrating tablets of. The purpose of the study was to improve the solubility of clonazepam in solid dispersions by incorporating hydroxypropyl methyl cellulose hpmc and poloxamer 407.

The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407. Coronary occlusion techniques during opcab may lead to an endothelial damage to the target vessel. See separate documents standard specification not for regulatory purposes available via basfs worldaccount. Basf pharmaceuticalgrade ingredients for the dermatology industry. You can find detailed information on our product range by looking up your industry or using our product finder. We would like to show you a description here but the site wont allow us. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181. All other chemicals and solvents used were ofpure analytical grade.

Apr 27, 2018 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. A critical requirement for cell survival after trauma is sealing of breaks in the cell membrane 111. The material is capable of formingmicelles 32 and can act as a coreagent in mesoporous. Process for producing a poloxamer gel download pdf. Poloxamer 188 p188 is an amphiphilic macromolecule shown to have plasma membranesealing properties in various cell types. Antiadherent biomaterials for prevention of catheter. Lee electrical trauma research program, departments of surgery, medicine and organismal biology and anatomy, the university of chicago, chicago, illinois 60637. Pge2 and poloxamer synperonic f108 enhance transduction of. Formulation and evaluation of fast dissolving films for. All poloxamer solutions were stored at 4 c prior to use and made fresh weekly. Catalase from bovine liver, xylenol orange sodium salt, and butylated hydroxytoluene. Article information, pdf download for safety assessment of poloxamers 101, 105, 108.

Sigmaaldrich offers a number of poloxamer 188 products. The right path to greater solubility and bioavailability. European journal of pharmaceutics and biopharmaceutics. Interaction between lipid monolayers and poloxamer 188. Three formulations were selected from the nanoemulsion region and their potential impact. It is used as an emulsifier, solubilizer, dispersing and wetting agent in the preparation of solid dispersions, and for the enhancement of the bioavailability of. It is a surfactant functioning both as cleansing and solubilizing agent. Raw materialinci name % ww trade namesupplier function phase a. Flocor lot 379153, the clinical grade of poloxamer 188, was a gift of cytrx corporation ga, usa and was used as received. Development and in vitroin vivo characterization nadia m.

To investigate whether p188 1 protects alveolus resident cells from necrosis and 2 is associated with reduced ventilator. In house triple, distilled water was used throughout the. Pdf synthesis and characterization of poloxamer 188grafted. This particular compound is also known by the basf trade name pluronic f127 or by the. In the present study, we investigate to the endothelial damage in the rat aorta which is occluded by poloxamer 407. What links here related changes upload file special pages permanent link page information. Makon l61 poloxamer 181 liquid 3 2,000 24 32 162 makon l62 poloxamer 182 liquid 7 2,500 32 41 268 makon l64 poloxamer 184 liquid 15 2,900 58 18 312 makon l101 poloxamer 331 liquid 1 3,800 15 36 392 makon p6575 na paste 17 3,800 82 27 2222 makon p104 poloxamer 334 paste 5,900 82 32 4482 makon p105 poloxamer 335 paste 15 6,500 631 36 6262. Method of preparation of drug loaded nanoparticles.

Apart from its use in manual sugar coating, kollidon va 64 or kollidon 30. Phages in a thermoreversible sustainedrelease formulation. Ch 3 hoch 2ch 2o xch 2cho ych 2ch 2o xh lutrol f 68 nf important. The nonclinical grade poloxamer 188 was a kind gift of basf aktiengesellschaft ludwigshafen, germany and was used as received unless chemically modified. The pluracare block copolymers cas 9003116 are synthetic copolymers of propylene oxide and ethylene oxide represented by the following chemical structure. Characteristics the character of each poloxamer in terms of. Evaluation of hydroperoxides in common pharmaceutical excipients. Resist agent for producing white and coloured resists, for example with procion px and p dyes under basilen f dyes. In addition, p 124 and p 188 are known to have suitable mucoadhesive force, low toxicity, less skin irritation, good drug release characteristics and. Deionized water was obtained from a millipore filtration system, usa. Poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900.

The mechanism by which poloxamer 188 p188 seals a damaged cell membrane is examined using the lipid monolayer as a model system. Pdf research for new therapies to treat diseases like cancer, it is one of the focus of health sciences. Hubmayr 1thoracic diseases research unit, division of pulmonary and critical care medicine, mayo clinic, rochester, minnesota. Poloxamer 188 facilitates the repair of alveolus resident cells in ventilatorinjured lungs maria plataki 1, yang d. Wounded alveolus resident cells are identified in human and experimental acute respiratory distress syndrome models. Thanks to its ability to affect viscosity, it may also be used as stabilizer for topically administered suspensions and is used in toothpastes, gargles and mouthwashes. Polypropylene chemical compatibility chart from ism.